Lacticaseibacillus casei, formerly known as Lactobacillus casei, is a type of bacteria classified within the field of probiotics, microorganisms that, when consumed in adequate amounts, grant health benefits to your digestive system. Particularly, L. casei Shirota is a well-studied strain, named after the Japanese scientist Minoru Shirota, who first isolated it. This strain has an established reputation for supporting gut health and has been shown to aid in regulating bowel movements, potentially enhancing your overall digestive function.
Your body can obtain L. casei Shirota through various fermented foods, such as yogurt and specific types of cheese, or through beverages like Yakult, a probiotic dairy product. Research suggests that consistent intake of L. casei Shirota can contribute to maintaining a balanced intestinal microbiota, which is crucial for proper digestion and can also play a role in preventing gastrointestinal conditions, like diarrhea. Furthermore, evidence from studies indicates that this probiotic strain may contribute to the reduction of uremic toxins in patients undergoing hemodialysis, highlighting its potential benefits beyond basic digestive health.
Overview of L. Casei Shirota
In examining L. Casei Shirota, you’re exploring a specific probiotic strain known for its health-related applications, originating from decades of research and innovation.
Bacterial Strain Classification
L. Casei Shirota is a strain of the species Lacticaseibacillus casei, which falls under the larger family known as Lactobacillaceae. As you understand, this is part of a group of lactic acid bacteria that is recognized for its acid tolerance and non-spore-forming characteristics. It is also facultatively anaerobic, meaning it can grow without oxygen, although it may use it if available.
Historical Background
The history of L. Casei Shirota dates back to the 1930s when Dr. Minoru Shirota first identified and cultivated this strain. Dr. Shirota’s work laid the foundation for the incorporation of this strain into various health products. Most notably, in 1955, Yakult Central Institute took over the research, ensuring the continuous study and development of this strain in alignment with probiotic efficacy and safety.
Health Benefits
Lactobacillus casei Shirota is a well-researched probiotic that offers a range of health benefits, particularly related to digestive health and immune function.
Probiotic Properties
L. casei Shirota is renowned for its ability to survive the acidic environment of the stomach, allowing it to reach the intestines where it can exert its beneficial effects. Its strong probiotic properties support a balanced gut microbiome, which is crucial for overall health.
Digestive Health
- Prevention of Constipation: Regular consumption of this probiotic strain has been linked to improved bowel movements, helping alleviate mild constipation.
- Lactose Intolerance Management: It can enhance lactase activity, making dairy more tolerable for those with lactose intolerance.
Immune System Support
L. casei Shirota has been shown to stimulate the immune system, improving your body’s defense against common pathogens. Further, it may reduce the incidence of certain allergies by modulating immune responses.
Dietary Sources
Lactobacillus casei Shirota (LcS) is commonly found in various dietary products that support your gut health. Here’s where you can find this beneficial bacterium.
Fermented Dairy Products
LcS is primarily present in fermented dairy products, being one of the key ingredients that contribute to their probiotic properties. Look for:
- Yogurt: Some yogurts are specifically cultured with LcS strains.
- Kefir: A fermented milk drink that may sometimes include LcS as part of its probiotic blend.
When choosing fermented dairy products, check the label to confirm the presence of LcS.
Supplements and Fortified Foods
For those who prefer or need non-dairy options, LcS is also available in other forms:
- Probiotic Supplements: These often come in capsules or powders and should list LcS among their strains.
- Fortified Foods: Certain health-focused food products are fortified with probiotics including LcS.
Ensure the supplement or fortified food product mentions LcS or Lactobacillus casei Shirota explicitly to guarantee you’re getting the right strain.
Scientific Research
Your understanding of Lactobacillus casei strain Shirota is supported by extensive scientific research, which demonstrates its impact on health, particularly gut health and immune function.
Clinical Studies
Clinical trials have documented the efficacy of L. casei Shirota. For example, a multicentre randomised, double-blind, placebo-controlled trial studied its effect in preventing antibiotic-associated diarrhea, including Clostridioides difficile infection in patients with spinal cord injuries. Another study showed that taking the probiotic three times daily for 2 weeks resulted in improved bowel function and a decrease in uremic toxins in patients undergoing hemodialysis.
Gut Microbiota Research
Investigations into how L. casei Shirota influences your gut microbiota reveal that this probiotic strain can survive the gastrointestinal tract’s harsh conditions. Research has confirmed its survivability across different populations, including studies validating these findings in the United States through fecal sample analysis. This survivability indicates L. casei Shirota’s potential to positively modulate your gut microbiota.
Safety and Regulations
In this section, you’ll find important details on the safety protocols surrounding L. casei Shirota and its regulatory compliance, which are critical for both healthcare providers and consumers.
Consumption Guidelines
When opting to include L. casei Shirota in your diet through probiotic supplements or fermented dairy products like Yakult, it is essential to follow the manufacturer’s recommended dosages. Clinical studies suggest that consuming this probiotic in typically suggested amounts is safe for most people, including those in vulnerable groups like children and seniors. However, you should consult with a healthcare provider before starting any new supplement, especially if you have underlying health conditions or are taking other medications.
Regulatory Status
The regulatory status of L. casei Shirota can vary by country, but it is generally recognized as safe under the Generally Recognized as Safe (GRAS) status by the U.S. Food and Drug Administration (FDA) when used as directed. In the European Union, probiotics fall under the Food Supplements Directive and must comply with strict safety and labeling requirements. To ensure compliance, manufacturers of L. casei Shirota must provide evidence of safety, and products must be adequately labeled to inform consumers of their correct usage.
Frequently Asked Questions
In this section, you’ll find targeted information on L. casei Shirota, addressing its health benefits, dosage, and how it compares to other probiotics.
What are the health benefits associated with L. casei Shirota strain?
The L. casei Shirota strain is recognized for its probiotic properties, supporting gut health and aiding digestion. It’s been studied for possibly improving bowel movement frequency and balancing intestinal flora.
How does the Shirota strain compare to other probiotics in terms of efficacy?
L. casei Shirota is comparable to other probiotics in promoting digestive health but has a unique profile due to the specific bacterial strain. Studies suggest that it may survive digestion and reach the intestines effectively.
What is the recommended dosage for Lactobacillus casei Shirota supplements?
While the optimal dosage can vary, clinical studies often use dosages ranging from 1×10^9 to 40×10^9 colony-forming units (CFU) to observe benefits. Always follow the product label or healthcare provider’s instructions.
Can L. casei Shirota improve digestive health, and if so, how?
Yes, L. casei Shirota has been associated with improved digestive health by possibly enhancing gut microbiota. It may help relieve mild constipation and improve overall bowel movement regularity.
Are there specific conditions or issues that L. casei Shirota is particularly effective in addressing?
L. casei Shirota may assist in managing conditions such as constipation, inflammatory bowel disease (IBD), and lactose intolerance. Moreover, its role in modulating immune responses could be beneficial for certain allergic skin conditions.
What should consumers look for when choosing a probiotic supplement containing the L. casei Shirota strain?
Consumers should check for the CFU count, ensuring it meets the effective range studied in research. The supplement should also guarantee viability of the strain through to the end of shelf life for maximum benefit.

Johan Theorin is an author, editor, and competitive cyclist. He is the author of most of the content on this website, and he is the site editor. Johan has spent years researching joint health, sports performance and recovery. He is a leading biohacking expert and an experienced physiotherapist.
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